The Kolkata campus of the Indian Statistical Institute is located in a sprawling 30-acre estate on the Barrackpore Trunk Road (B.T. Road) in the Baranagore suburb of Greater Kolkata. It consists of two approximately equal parts - the office complex and the residential complex, - separated by a public road. This road (Girish Chand Ghosh Street) connects B.T. Road with Gopal Lal Tagore Road, a road which runs along the western boundary of the main campus. The office complex bears door numbers 202, 203 and 204, and the residential complex, 205 and 206. There is no connection between the two parts of the campus; to move between the residential and office complexes, one has to come out on B.T. Road and enter the other campus. There is also a narrow public road that separates 202 and 203 B.T. Road. There is however, a direct connection between these two premises.
The principal buildings in the office complex are the Main Bulding, the Geology Building, the Library Building, the Administration Building and the Amrapali. The residential campus at 205 and 206 B.T. Road premises includes, apart from several staff quarters, the Guest House, the Medical Welfare Unit, the Boys' Hostel, the Research Scholars' and ISEC hostel, the Ladies hostel, and parts of several service units. Some residential quarters are located in Deluxe Garden, an enclaved located on the west side of the Gopal Lal Tagore Road, near the office campus. ISI also owns Gupta Nivas, a property located on the east side of B.T. Road, north of the office campus. This building has a remarkable history, but is no longer in use.
The construction of the Senior Boys' Hostel (popularly called the Research Scholars' Hostel or RS Hostel) was completed in 1989. Apart from the research fellows, M.Tech. students also stay in this hostel. One section of the hostel is reserved for the international students of the International Statistical Education Centre (ISEC).